摘要
Abstract
Objective:To investigate the effects of Dexmedetomidine on the postoperative recovery of patients with cranioplasty under general anesthesia.Method:Sixty-three ASA Ⅰ or Ⅱ patients with cranioplasty admitted to our hospital from February 2008 to November 2013 were selected as research objects,they were randomly divided into the group D1 (Dexmedetomidine dosage was 0.5 g/kg),the group D2(Dexmedetomidine dosage was 1.0 g/kg) and the group C(the normal saline control group),21 cases in each group.The same induction and maintenance of general anesthesia were used in each group. At the time of suturing scalp,Dexmedetomidine 0.5 µg/kg and 1.0 µg/kg were infused by micropump within ten minutes in group D1 and group D2 respectively,while the equal volume of 0.9% normal saline was administered instead of Dexmedetomidine in group C.Restlessness scores(RS) were assessed and recorded at immediately(T1) and 5,10,30 minutes(T2,T3,T4 respectively) after extubation.The operation time,extubation time(from infusion of Dexmedetomidine or normal saline to tracheal extubation),the time of leaving the operating room(from tracheal extubation to leaving the operating room) were recorded. The incidence of the nausea,vomiting,reflective coughing and adverse cardiovascular events were recorded in the process of awakening.Result:There were no statistically significant differences in the extubation time,the time of leaving the operating room and operation time among the three groups(P>0.05).At time point of T1,T2,T3,T4,the RS of the group D1 and the group D2 were significantly lower than the group C,the differences were statistically significant(P<0.05),otherwise there was no statistically significant difference in RS between group D2 and group D1 meanwhile(P>0.05).The incidence of reflective coughing in the group D1 and the group D2 were significantly lower than the group C,and the incidence of adverse cardiovascular events in the group D1 was significantly lower than the group D2 and the group C,the differences were statistically significant (P<0.05).Conclusion:When suturing scalp,infusion of Dexmedetomidine 0.5 µg/kg can improve the quality of postoperative recovery of patients with cranioplasty and is more effective and safer.关键词
右美托咪定/颅骨缺损/全身麻醉/恢复期Key words
Dexmedetomidine/Skull defect/General anesthesia/Recovery period
