摘要
Abstract
Objective To investigate the relationship among expression of ERCC-1,BRCAI,Survivin and prognosis in non-small cell lung cancer treated by platinum,Taxane-based chemotherapy. Methods The protein expression of ERCC-1,BRCA-1 and Survivin were detected by immunohistochemistry(IHC)in 74 patients. The relation between expression level of ERCC-1, BRCA-1, Survivin and prognosis was analyzed. Results ( 1 ) ERCC-1 expression rate was 60. 81%, while gender, age, stage, pathology and history of smoking were irrele-vant. The high expression rate of ERCC-1 was 45. 45% in the patients reveiving chemo and 83. 33% in the in-effective chemotherapy patients(P =0. 001). (2)BRCA-1 expression rate was 59. 46%,while gender, age, stage were irrelevant, but correlation with pathology and history of smoking were relevant. The high expression of BRCA-1 was 47. 33% in the patients reveiving chemo and 76. 67% in the ineffective chemotherapy patients (P=0. 016). (3)Survivin expression rate was 40. 91%, while gender, age, stage, pathology and history of smoking were irrelevant. The high expression of Survivin was 40. 91% in the chemotherapy patients and 66. 67% in the ineffective chemotherapy patients(P=0. 035). Conclusions The expression rate of ERCC-1, BRCA-1 and Survivin may provide important predictive value for chemotherapy in non-small cell lung cancer.关键词
ERCC-1/BRCA-1/Survivin/非小细胞肺癌/多西他赛/顺铂Key words
ERCC-1/BRCA-1/Survivin/non-small cell lung cancer/docetaxel/cisplatin
