中华神经创伤外科电子杂志Issue(3)：4-7,4.DOI:10.3877/cma.j.issn.2095-9141.2015.03.002
早期高压氧治疗对重型颅脑损伤患者术后神经功能的影响
Effects of early hyperbaric oxygen therapy on postoperative neurological function of severe craniocerebral injury patients
摘要
Abstract
Objective To investigate the effects of early hyperbaric oxygen treatment on patients with severe craniocerebral injury on the postoperative neurological function. Methods A total of seventy eight patients with severe traumatic brain injury in recovery period after surgical op-eration were selected for this study. According to the intervention time of hyperbaric oxygenation, they were randomly divided into early group (HBOT within 3 days after operation, n=38) and control group (HBOT without 7 days after operation, n=40). Dynamic head CT scan was performed for detecting and determine the duration of brain edema. Patients’ consciousness were assessed in 1, 2, 3, 4 weeks after the operation by GCS (Glasgow Coma Scale) and the neurological function were performed l, 2, 3 months after the operation by NIHSS (National Institutes of Health Stroke Scale). Results Compared with the control group (12.65 ± 4.42) d, the duration of brain edema in early group (10.39 ± 4.05) d was significantly reduced(P<0.05). The GCS scores were (7.68 ± 1.49), (9.38 ± 1.51), (10.28 ± 1.55), (11.13±1.68) after operation 1, 2, 3, 4 weeks in control group, respectively;and the early group were (8.63 ± 1.28), (10.08 ± 1.26), (11.03 ± 1.31), (12.13 ± 1.32), respectively. Compared with the control group, the GCS score in early group was significantly increased (P<0.05). The NIHSS scores were (13.55 ± 2.54), (9.05 ± 2.46), (6.43 ± 2.19) after operation 1, 2, 3 months in control group, respectively;and the early group were (12.05 ± 2.09), (7.90 ± 2.14), (5.24 ± 1.98). Compared with the control group, the neurological defections were significantly reduced in early group (P<0.05). Conclusion Early hyperbaric oxygen treatment on severe traumatic brain injury patients after surgery can shorten the dura-tion of brain edema significantly, improve the state of consciousness and reduce the neurological func-tion impairment.关键词
颅脑损伤/高压氧疗法/脑水肿/格拉斯哥昏迷评分Key words
Craniocerebral injury/Hyperbaric oxygenation/Brain edema/Glasgow co-ma scale引用本文复制引用
疏龙飞,刘家传,郑彩芬,王金标,张永明,张星,王春琳,杨艳艳,马涛,杨小兰..早期高压氧治疗对重型颅脑损伤患者术后神经功能的影响[J].中华神经创伤外科电子杂志,2015,(3):4-7,4.基金项目
全军医学科技“十二五”科研项目(面上)(编号CWS11J262)；南京军区联勤部卫生部十一五重点基金项目(编号06Z19) （面上）
