发光学报Issue(9)：989-995,7.DOI:10.3788/fgxb20153609.0989
叶酸修饰的AgInS2量子点在体外癌细胞成像上的应用
Folic Acid-conjugated AgInS2 Quantum Dots for in vitro Cancer Cell Imaging
摘要
Abstract
AgInS2 quantum dots ( QDs) were synthesized using hot colloidal method and transferred into water via a ligand exchange route. To enhance the stability of these QDs, dBSA was coated on the aqueous QDs as a ligand shell. After dBSA modification, a size increase was observed from the transmission electron microscopy ( TEM) re-sults. The prepared dBSA-MPA QDs exhibited good monodispersity, enhanced stability ( stable for 4 weeks) and bright photoluminescence. Then the QDs were functionalized with folic acid ( FA) and the successful conjugation was confirmed by the Fourier transform infrared ( FT-IR) spectroscopy. The resulting FA-dBSA-MPA QDs nanocomposites were tested in breast cancer cells ( MCF-7 cells) with elevated folate receptor expression. Compared to the unconju-gated dBSA-MPA QDs, the presence of FA on the surface of QDs significantly improved the uptake rate of the nanop-articles by the cancer cells.关键词
AgInS2/量子点/荧光/体外/细胞成像Key words
AgInS2/quantum dots/fluorescence/in vitro/cell imaging分类
数理科学引用本文复制引用
卜承飞,刘丽炜,王倩,张卜天,胡思怡,任玉,朱泠西..叶酸修饰的AgInS2量子点在体外癌细胞成像上的应用[J].发光学报,2015,(9):989-995,7.基金项目
国家自然科学基金(11204020) （11204020）
吉林省国际纳米光子学与生物光子学重点实验室支撑项目(20140622009JC) （20140622009JC）
长春市科技计划(14GH005)资助项目 （14GH005）
