摘要
Abstract
Objective: To analyze retrospectively the age tendency, the related factors and the diagnosis and treatment in those patients with cervical intraepithelial neoplasias (CIN) in recent 10 years. Methods:A total of 2 192 patients with CIN, who had a surgical treatment, in our hospital from January 2004 to December 2013 were retrospectively analyzed. The clinical data were collected including the age ,pregnant history, HR-HPV infection, operation style, the rate of pathological coincidence between postoperation and preoperation, so as to analyze the incidence of CIN, risk factor and treatment method. Results: ①In the recent 10 years,the number of CIN patients increased year by year and the proportion of CIN in all surgical patients of gynecology also steadily increased. The age between 30 and 40 years was of high risk. The number of CIN patients without pregnancy in latter five years was more than that in front five years (P<0.001). ②In 621 patients received HPV test, the infection rate was 95.65%, and the positive rate of HPV16 was the highest,followed by HPV58 and HPV52. The infection rate of multiple HPVs was 43.09% in those positive patients. The infection rates of HPV in the CIN Ⅲand cervical cancerⅠA1 groups were significantly higher than that in the CINⅡ group (P<0.05). There was significant difference in the infection rates of HPV among the CINⅢ group,the cervical cancerⅠA1 group and the groups of higher-grading cervical cancer (P>0.05). ③The rate of pathological coincidence between postoperation and preoperation was 76.73%.④75.27%of patients with CINⅡand higher-grading cervical lesions were treated with cold knife conization (CKC) as the primary surgical procedure. Conclusions:The incidence of CIN was increasing year by year,especially in those young women without pregnancy. The infection of HR-HPV is closely related to CIN. The CKC is of choice surgical treatment for those patients with CIN Ⅱ and higher-grading cervical lesions.关键词
宫颈上皮内瘤样病变/年龄因素/乳头状瘤病毒科/宫颈肿瘤/病理学Key words
Cervical intraepithelial neoplasia/Age factors/Papillomaviridae/Uterine cervical neoplasms/Pathology
