中国实用神经疾病杂志Issue(18)：4-6,3.
氯吡格雷联合阿司匹林与低分子肝素联合阿司匹林治疗短暂性脑缺血发作近期疗效观察
Comparative observation of Clopidogrel and Aspirin versus Low-molecular-weight Heparin and Aspirin in transient ischemic attack patients
刘艳 1刘文鹏 1魏灿 1张艳荣 1丁云龙1
作者信息
- 1. 江苏靖江市人民医院神经内科 靖江 214500
- 折叠
摘要
Abstract
Objective To compare the clinical efficacy of clopidogrel and aspirin(ASA) versus low‐molecular‐weight hepa‐rin(LMWH) and aspirin in patients with transient ischemic attack(TIA) .Methods 102 cases with TIA were classified into two groups according to the ABCD3‐I scores:low risk group (ABCD3‐I <4 scores) and moderate‐high risk group(ABCD3‐I ≥4 scores) .Furthermore ,two groups were randomly divided into ASA subgroup ( clopidogrel and aspirin ) and LMWH subgroup (low‐molecular‐weight heparin and aspirin ) .We recorded control rate to assess therapeutic effect and presented adverse events within 7‐day treatment ,and kept 1‐month follow‐up .Results In low risk group ,the control rate in ASA subgroup (97 .6% ) was slightly higher than that in LMWH subgroup (95 .1% ) .And conversely ,in moderate‐high risk group ,LMWH subgroup (90 .0% ) obtained the higher control rate than ASA subgroup (80 .0% ) with no statistical difference .Although the adverse e‐vents in ADR subgroup were less than that in LMWH subgroup ,there was no significant difference in terms of incidence .Con‐clusion The present study demonstrates that low risk patients with ABCD3‐I <4 scores should consider the therapy of clopi‐dogrel and aspirin as first choice ,and as for moderate‐high risk patients with ABCD3‐I ≥4 scores ,low‐molecular‐weight hepa‐rin and aspirin maybe has better short‐time efficacy than clopidogrel and aspirin .关键词
氯吡格雷/低分子肝素/阿司匹林/短暂性脑缺血发作Key words
Clopidogrel/Low-molecular-weight heparin/Aspirin/Transient ischemic attack分类
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刘艳,刘文鹏,魏灿,张艳荣,丁云龙..氯吡格雷联合阿司匹林与低分子肝素联合阿司匹林治疗短暂性脑缺血发作近期疗效观察[J].中国实用神经疾病杂志,2015,(18):4-6,3.
