军事医学Issue(8)：621-625,5.DOI:10.7644/j.issn.1674-9960.2015.08.012
低分子肝素对慢性阻塞性肺疾病急性加重治疗效果的Meta分析
Effects of low molecular weight heparin on patients with AECOPD:a meta-analysis
周凌 1席家宁1
作者信息
- 1. 辽宁医学院航天中心医院研究生培养基地，北京 100049
- 折叠
摘要
Abstract
Objective To estimate the effect of low molecular weight heparin (LMWH) combined with conventional treatment on patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Literature on randomized control trials( RCTs) with AECOPD treated by LMWH combined with conventional methods was collected in PubMed.The studies were selected according to inclusive and exclusive criteria.The data were extracted,the quality was assessed, and meta-analysis was conducted with RevMan 5.2 software.Results There were twelve RCTs including 879 patients with AECOPD in the current study.The results of meta-analysis showed that:①LMWH could obviously improve PaO2 and PaCO2 of patients with AECOPD as compared with the control group.②There was no statistically significant difference between the LMWH-treated group and control group in the improvement of FEV1 or hematocrit.Conclusion LMWH can significantly improve arterial blood gas analysis in AECOPD, but does not improve FEV1 or hematocrit.关键词
肺疾病,慢性阻塞性/急性加重/低分子肝素/Meta分析/系统评估/随机对照试验Key words
chronic obstructive pulmonary disease/acute exacerbation/low molecular weight heparin/meta-analysis/system assessment/randomized control trial分类
医药卫生引用本文复制引用
周凌,席家宁..低分子肝素对慢性阻塞性肺疾病急性加重治疗效果的Meta分析[J].军事医学,2015,(8):621-625,5.
