军事医学Issue(8)：626-628,651,4.DOI:10.7644/j.issn.1674-9960.2015.08.013
重症急性胰腺炎的血浆TFPI水平和诊断价值
Diagnostic value of plasma tissue factor pathway inhibitor in patients with severe acute pancreatitis
摘要
Abstract
Objective To examine the levels of plasma tissue factor pathway inhibitor (TFPI) in patients with acute pancreatitis (AP) to assess the clinical value of diagnosis for severe acute pancreatitis ( SAP).Methods Sixty-eight patients were divided into mild acute pancreatitis (MAP)group (n=36) and SAP group (n=32), and twenty volunteers were chosen into normal group ( n=20 ) .Clinical data of these patients were collected, including APACHEⅡscore and Ranson score.Plasma levels of TFPI were measured by ELISA.Results The plasma levels of TFPI in SAP group, MAP group and control group were (4274.25 ±639.83),(3026.81 ±465.76) and (2468.73 ±262.39)pg/ml, respectively(P<0.05).There were significant positive correlations between TFPI and WBC, AST, ALT, TBIL, Cr, PT, APTT, PCT, APACHEⅡscore and Ranson score (P<0.05).The area under the curve (AUC) of TFPI for SAP was 0.902(95%CI=0.845 -0.959, P<0.05 ) .The cutoff value was 4028.83 pg/ml for plasma TFPI with a sensitivity of 87% and a specificity of 78%.Conclusion Plasma levels of TFPI in patients with SAP are significantly increased, which maybe help diagnose SAP.关键词
急性胰腺炎,重症/组织因子途径抑制物/血浆/诊断Key words
acute pancreatitis,severe/TFPI/plasma/diagnosis分类
医药卫生引用本文复制引用
陈荣剑,宋景春,许永春,朱洪亮,陈自力,钱红军,林青伟..重症急性胰腺炎的血浆TFPI水平和诊断价值[J].军事医学,2015,(8):626-628,651,4.基金项目
南京军区重点科技创新项目（2013 ZD22）；江西省卫计委科技计划课题 （）
