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补体5a与急性肺损伤关系研究进展

杨丽梅赵建丁日高

军事医学Issue(8)：633-636,4.

军事医学Issue(8)：633-636,4.DOI:10.7644/j.issn.1674-9960.2015.08.015

补体5a与急性肺损伤关系研究进展

Advances in research on relationships between complement 5a and acute lung injury

杨丽梅 ¹赵建 ²丁日高¹

作者信息

1. 军事医学科学院毒物药物研究所，抗毒药物与毒理学国家重点实验室，北京 100850
2. 武警后勤学院防护医学教研室，天津 300309
折叠

摘要

Abstract

Acute lung injury ( ALI) is a type of pulmonary excessive inflammation with high morbidity and mortality.It can be induced by multiple causes.There are currently no successful therapeutic or preventive measures because the patho-genesis of ALI has not been completely clarified.Many studies have shown that the activation of complement 5a (C5a) and its receptors is necessary in the process of ALI.Drug development targeting on C5a and its receptors may bring new hope to the treatment of ALI.In this article, the experimental evidence and possible mechanisms are summarized to reveal the rela-tionship between C5a and ALI.

关键词

补体/C5a/急性肺损伤/C5aR/C5L2

Key words

complement/C5a/acute lung injury/C5aR/C5L2

分类

医药卫生

引用本文复制引用

杨丽梅,赵建,丁日高..补体5a与急性肺损伤关系研究进展[J].军事医学,2015,(8):633-636,4.

基金项目

全军医学科研“十二五”重点项目（）

军事医学

OA北大核心CSCDCSTPCD

ISSN：1674-9960

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