药学研究Issue(9)：500-502,511,4.
胡椒中提取纯化胡椒碱的工艺研究
Studies on extraction and purification for piperine from Piper nigrum L.
摘要
Abstract
Objective To study industrial technology for the extraction and purification of piperine from Piper nigrum L. . Methods Piperine from blacK pepper is extracted and separated with 85% ethanol,and the purity of piperine was det-emined by HPLC. With extraction rate and purity of piperine as index,extraction and purity technology of piperine from Pip-er nigrum L. was optimizied. Results Finally the optimum conditions were extracting and separating piperine from blacK pepper with 85% ethanol by 2 times,ethanol(volume)∶pepper(quality)(10∶1). The filtrate was combined,condensed, and then dynamic cooling crystallization. The crude product of piperine was crystallized many times with anhydrous ethanol. The purity of piperine was more than 98% . Conclusion Extraction and purification technology of piperine used in this study was simple and maneuverability,and the purity of product was high. It was suitable for industrial production.关键词
胡椒/胡椒碱/回流提取/结晶/产业化Key words
Piper nigrum L./Piperine/Reflux extraction/Crystallization/Industralization分类
医药卫生引用本文复制引用
徐士明,关永霞,朱祥霞,武洪英..胡椒中提取纯化胡椒碱的工艺研究[J].药学研究,2015,(9):500-502,511,4.基金项目
国家科技部973项目课题 （）
