中国组织工程研究Issue(34)：5485-5490,6.DOI:10.3969/j.issn.2095-4344.2015.34.015
疏水性丙烯酸酯折叠式人工晶体的生物安全性
Biological safety of hydrophobic acrylic foldable intraocular lens
段晓杰 1姜宝光 2王召旭1
作者信息
- 1. 中国食品药品检定研究院，北京市 100050
- 2. 沈阳百奥医疗器械有限公司，辽宁省沈阳市 110163
- 折叠
摘要
Abstract
BACKGROUND:Hydrophobic acrylic foldable intraocular lens should be evaluated biologicaly with New Zealand rabbits as implant objects prior to clinical trial. OBJECTIVE:To observe the biological safety of hydrophobic acrylic foldable intraocular lens. METHODS: Twelve New Zealand rabbits were enroled. The right eyes were implanted with self-developed hydrophobic acrylic foldable intraocular lens (Shenyang Baiao Medical Device Co., Ltd., China) as experimental group, and the left eyes were implanted with Acrysof IQ SN60WF (Alcon, USA) as control group. RESULTS AND CONCLUSION: After implantation, there were no significant differences in the cornea, anterior chamber, implant position, posterior segment of eyebal between two groups. Tissue proliferation had no obviously difference between the two groups, and there were cornea and lens pouch inflammations. No macrophages and other inflammatory cels were visualized on the surface of intraocular lens, and fibrous tissues were found on the intraocular lens surface and in the haptics root. These findings suggest that the self-developed hydrophobic acrylic foldable intraocular lens has no difference from Acrysof IQ SN60WF widely used in clinic, and it has the biological safety.关键词
生物材料/材料相容性/疏水性丙烯酸酯/人工晶体/家兔/长期植入/组织相容性/角膜/前房/晶状体Key words
Lenses, Intraocular/Inflammation/Materials Testing分类
医药卫生引用本文复制引用
段晓杰,姜宝光,王召旭..疏水性丙烯酸酯折叠式人工晶体的生物安全性[J].中国组织工程研究,2015,(34):5485-5490,6.
