中国组织工程研究Issue(34)：5501-5505,5.DOI:10.3969/j.issn.2095-4344.2015.34.018
可降解涂层雷帕霉素洗脱支架在冠状动脉狭窄病变处理中的安全性
Biodegradable sirolimus eluting stents in coronary artery stenosis：a safety evaluation
迟新栋 1玛依努尔·斯买拉洪 2甘庆雷 1杨娜1
作者信息
- 1. 新疆医科大学附属中医医院高血压科，新疆维吾尔自治区乌鲁木齐市 830000
- 2. 新疆医科大学附属中医医院干一科，新疆维吾尔自治区乌鲁木齐市 830000
- 折叠
摘要
Abstract
BACKGROUND:Coronary artery stents can be used in clinical treatment of various lesions due to coronary artery stenosis, and different types of drug-eluting stents and bare metal stents can be used surgicaly. However, there are some differences in the therapeutic efficacy and safety among the stents made in different manufacturers. OBJECTIVE:To explore the safety of biodegradable sirolimus eluting stents from different manufacturers in the treatment of coronary artery stenosis. METHODS:Totaly 193 patients with coronary artery stenosis were enroled, including 116 males and 80 females, aged 37-81 years old. These patients were equaly divided into two groups and respectively treated with Firebird stent (MicroPort) and Partner stent (LOOP INC). Patients were folowed up for 12 months, and the restenosis rate,incidence of acute myocardial infarction, rate of coronary artery bypass graft or secondary percutaneous coronary artery interventional therapy, and mortality rate were compared between two groups. RESULTS AND CONCLUSION:After 12 months of folowed-up, there was no difference in the restenosis rate, incidence of acute myocardial infarction, rate of coronary artery bypass graft or secondary percutaneous coronary artery interventional therapy, and mortality rate between two groups (P> 0.05). During the folow-up, no adverse reaction occurred in both two groups. These findings indicate that different brands of biodegradable sirolimus eluting stents can obtain good outcomes in the treatment of coronary artery stenosis, have no adverse reaction, and exhibit a certain degree of security.关键词
生物材料/缓释材料/药物洗脱支架/雷帕霉素/冠状动脉狭窄/介入治疗/再狭窄率/安全性/生物相容性Key words
Sirolimus/Drug-Eluting Stents/Coronary Stenosis分类
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迟新栋,玛依努尔·斯买拉洪,甘庆雷,杨娜..可降解涂层雷帕霉素洗脱支架在冠状动脉狭窄病变处理中的安全性[J].中国组织工程研究,2015,(34):5501-5505,5.
