中国组织工程研究Issue(34)：5536-5540,5.DOI:10.3969/j.issn.2095-4344.2015.34.024
新型β钛合金Ti35Nb3Zr2Ta在人工关节假体应用中的生物相容性
Biocompatibility of Ti35Nb3Zr2Ta, a new beta-titanium alloy, as joint prosthesis material
摘要
Abstract
BACKGROUND:Ti6Al4V is a titanium aloy that is widely used in human joint replacement, but its modulus of elasticity is greater than human bone, resulting in the bad stability of the prosthesis. Ti35Nb3Zr2Ta, a new βtitanium aloy, has a lower modulus of elasticity, and maybe becomes a new-generation human joint prosthesis material that has a better biocompatibility. OBJECTIVE:To study the biocompatibility of Ti35Nb3Zr2Ta in prosthesis. METHODS:Wanfang, CNKI and PubMed databases were retrieved using a computer with “new β titanium;prosthesis; biocompatible” as keywords, and the retrieval time ranged from 2010 to 2015. Articles focusing on current application status for medical prosthesis materials and the biocompatibility of Ti35Nb3Zr2Ta in prosthesis were selected. RESULTS AND CONCLUSION:Compared with Ti6Al4V, Ti35Nb3Zr2Ta has higher surface roughness and smaler surface contact angle; the alkaline phosphatase activity and amount of calcium deposits in osteoblasts cultured at Ti35Nb3Zr2Ta is significantly higher than that at Ti6Al4V. Ti35Nb3Zr2Ta has good biocompatibility, and can be considered to be widely used as joint prosthesis material further.关键词
生物材料/材料相容性/新型β钛合金/Ti35Nb3Zr2Ta/人工关节假体/生物相容性/表面粗糙度/碱性磷酸酶活性/矿化/金属材料Key words
Titanium/Joint Prosthesis/Biocompatible Materials/Bioprosthesis分类
医药卫生引用本文复制引用
段永刚,丁英奇,张龙,刘玉章,唐晓龙..新型β钛合金Ti35Nb3Zr2Ta在人工关节假体应用中的生物相容性[J].中国组织工程研究,2015,(34):5536-5540,5.基金项目
张家口科技局与地震局自筹项目(1321120D)@@@@ the Self-Raised Project of Zhangjiakou Technology Bureau and Seismological Bureau, No.1321120D （1321120D）
