新医学Issue(8)：528-531,4.DOI:10.3969/g.issn.0253-9802.2015.08.009
不同血液净化方法的组合对血液透析患者矿物质和骨代谢的影响
Influence of different combinations of hemopurification methods on mineral and bone metabolism in he-modialysis patients
摘要
Abstract
Objective To compare the effect of different combinations of hemopurification methods on mineral and bone metabolism in hemodialysis patients.Methods A total of 96 patients with end-stage renal disease were divided into three groups according to the different hemopurification treatments that they received:group A received conventional hemodialysis,group B received a combination of conventional hemodialysis and hemodiafiltration,and group C received a combination of conventional hemodialysis and hemoperfusion.Intra-group and intergroup comparisons of changes in serum calcium,phosphorus,intact parathyroid hormone (iPTH),bone density and T value after 6 months of treatment were performed in these 3 groups.Results No statistically significant differences in serum calcium,phosphorus,iPTH,bone density,and T values were iden-tified among the three groups before and after treatment (P >0.05).An elevated serum phosphorus level was observed after treatment in group A (P <0.05),which was not observed in the other two groups.The iPTH level of group C decreased after treatment (P <0.05).No significant changes in bone density and T values were observed after treatment within each of the three groups (P >0.05).Conclusions A combination of conventional hemodialysis and hemodiafiltration or a combination of conventional hemodialysis and hemoperfu-sion can stabilize serum phosphorus levels,while a combination conventional hemodialysis and hemoperfusion facilitates the reduction of the blood iPTH level.Different combinations of hemodialysis methods exerted no sig-nificant short term effects on the bone density of the patients.关键词
矿物质骨异常/血液透析/血液灌流/血液透析滤过/终末期肾脏病Key words
Mineral and bone disorder/Hemodialysis/Hemoperfusion/Hemodiafiltration/End-stage renal disease引用本文复制引用
漆映辉,曲晓璐,唐咏华,张善宝,岑洁,倪兆慧..不同血液净化方法的组合对血液透析患者矿物质和骨代谢的影响[J].新医学,2015,(8):528-531,4.基金项目
上海市浦东新区卫计委学科带头人培养计划附带课题 （）
