医药导报Issue(9)：1135-1139,5.DOI:10.3870/j.issn.1004-0781.2015.09.003
异常黑胆质成熟剂对银屑病模型小鼠的治疗作用∗
Therapeutic Effect of Munziq Sawda on Mouse Psoriasis Model
摘要
Abstract
Objective To study anti-psoriasis effect of Munziq Sawda on mouse model. Methods We established the mouse tail scale epidermis and psoriasis-like skin inflammation model by applying 5%propranol hydrochloride emulsion on mouse ears,and then observed body weight,thymus and spleen index,measured IL-10 ,IL-17,IL-23 secretion in serum with ELISA method, and also detected istopathological changes of the skin of tail and ears in mouse. Results No obvious abnormalities were found of general condition and body weight ( P> 0.05) during the experiment period in the Munziq Sawda treated groups(2,4,8 g•kg-1 ) ; Compared with the model control group,2 g•kg-1 Munziq Sawda decreased thymus index (2.841±1.211)vs(1.903±0.885) mg•g-1(P<0.05); Munziq Sawda at 2,4,8 g•kg-1 did not obviously impact on the serum level of IL-10,IL-17 and IL-23 ( P>0.05); Munziq Sawda 2,4,8 g•kg-1 promoted the formation of epidermis granular layer in mouse tail and improved histopathological changes of the mouse ear skin. Conclusion Munziq Sawda has therapeutic action on experimental psoriasis model.关键词
异常黑胆质成熟剂/银屑病,实验性/指数,胸腺Key words
Munziq Sawda/Psoriasis ,experimental/Index,thymus分类
医药卫生引用本文复制引用
热比姑丽•伊斯拉木,尤力都孜•买买提,买合素提•卡德尔,斯拉甫•艾白..异常黑胆质成熟剂对银屑病模型小鼠的治疗作用∗[J].医药导报,2015,(9):1135-1139,5.基金项目
新疆维吾尔自治区公益性科研院所项目(KY201302) （KY201302）
