医药导报Issue(9)：1155-1157,3.DOI:10.3870/j.issn.1004-0781.2015.09.008
钩藤总碱对高血压动脉压力感受反射和对高血压靶器官的作用∗
Effects of Total Alkaloids of Rhynchophylline on Baroreflex and Hypertensive Target Organs in Spontaneous Hypertensive Rats
摘要
Abstract
Objective To investigate the effect of total alkaloids from Rhynchophylline on hypertensive target organs. Methods 40 spontaneous hypertensive rats (SHRs) were divided into 4 groups as follows: normal control group,positive control with Tianma Goutengyin granule at 750 mg•d-1 ,total alkaloids from Rhynchophylline at 2.5 mg•day-1 as low dosage,and at 15.0 mg•d-1 as high dosage.All the rats were fed up for 20 weeks,and baroreflex sensitivity (BRS,in ms•mmHg-1)was determined by revised Smyth’s method.Heart,brain and kidney of the rats were sectioned for histological analysis at the end of 20th week. Results In sixteenth weeks,BRS of positive control,Tianma Goutengyin granule group,total alkaloids at low dosage and high dosage were(0.27±0.05),(0.31±0.06),(0.35±0.08),(0.34±0.08) ms•mmHg-1,respectively.BRS in SHR was not decreased except in the positive control.The treatment groups were superior to the normal control group in structure of heart,but not in the brain and kidney of the rats. Conclusion Total alkaloids from Rhynchophyllinecould protect heart from hypertensive injury.关键词
钩藤总碱/高血压/损伤,靶器官/动脉压力感受反射Key words
Total alkaloids from Rhynchophylline/Hypertension/Injury ,target organs/Baroreflex分类
医药卫生引用本文复制引用
刘叶玲,王中师,张许..钩藤总碱对高血压动脉压力感受反射和对高血压靶器官的作用∗[J].医药导报,2015,(9):1155-1157,3.基金项目
山东省科技发展计划项目(2008GG2-NS02006) （2008GG2-NS02006）
