医药导报Issue(9)：1181-1184,4.DOI:10.3870/j.issn.1004-0781.2015.09.016
不同剂量盐酸右美托咪定鞘内注射对盐酸罗哌卡因蛛网膜下腔阻滞效果的影响∗
Effects of Different Doses of Dexmedetomidine Hydrochloride Intrathecal Injection on Ropivacaine Spinal Block
摘要
Abstract
Objective To investigate the effects of intrathecal different doses of dexmedetomidine hydrochloride in spinal block by ropivacaine hydrochloride . Methods Forty lower limb surgery scheduled for elective under spinal anesthesia, were randomly divided into 2 groups (n = 20 each): the control and the treatment groups.The control and the treatment group were intrathecally injected with 4,12 μg dexmedetomidine hydrochloride respectively.The 0.75% ropivacaine hydrochloride 1.5 mL was injected for spinal anesthesia.SBP,DBP,HR,SpO2 and Ramsay Sedation Score were recorded before the spinal anesthesia conduct and thereafter every five minutes. And the onset and duration of block were recorded,adverse reaction like nausea, vomiting and respiratory depression were also observed. Results Compared with the control group,the onset of sensory block was shorter [(6.9±2.6) min vs (8.7±2.9) min] (P<0.05),and the duration of sensory and motor block was longer in the treatment group[(130.8±30.1) min vs (115.9±23.9) min] (P<0.05) and [(145.9±29.0) min vs (130.0±30.1) min] (P<0.05). Conclusion Intrathecal dexmedetomidine hydrochloride at 12 μg improves anesthesia via shortening the sensory block onset and prolonging sensory and motor block,which maintains hemodynamically stable,and does not generate adverse reactions as nausea,vomiting,bradycardia and respiratory depression.关键词
右美托咪定,盐酸/注射,脊髓/麻醉,脊椎Key words
Dexmedetomidine hydrochloride/Injections,spinal/Anesthesia,spinal分类
医药卫生引用本文复制引用
姜景卫,鲁华荣,毛桂琴,祝雪芬,毛晨俊..不同剂量盐酸右美托咪定鞘内注射对盐酸罗哌卡因蛛网膜下腔阻滞效果的影响∗[J].医药导报,2015,(9):1181-1184,4.基金项目
浙江省医学会临床科研基金资助项目(2012ZYC-A93) （2012ZYC-A93）
