摘要
Abstract
Objective Based on measurement of chronic urticaria patients serum IL-4 and IL-8,IL-17 and IL-22 before and after 18 beta glycyrrhizin in the treatment of glycyrrhizin mechanism on treating chronic urticaria. Methods The levels of serum IL-22,IL-8,IL-17 and IL-4 in 20 cases of chronic urticaria were detected by blot Western assay and 20 cases of healthy controls. Results In patients with chronic urticaria by 18 beta glycyrrhizin treatment IL and serum concentrations of IL- 4(22.75 ± 6.87pg/ml),IL- 8 concentration(20.26 ± 4.52pg/ml),IL- 17 concentration(24.62 ± 7.28pg/ml)and IL- 22 concentration (23.26±9.04pg/ml),higher than the healthy control group(P<0.05).After the treatment, concentration of IL-4 was(14.44±4.29pg/ml),IL-8 concentration(12.24±3.32pg/ml),IL-17 concentration(13.32±1.61pg/ml), IL-22 concentration(14.32 ± 1.59pg/ml),treatment significantly decreased (P<0.05),and healthy control difference no statistical significance(P>0.05). Conclusion The serum of patients with chronic urticaria of IL-4 and IL-8,IL-17 and IL-22 levels different from normal,suggesting that chronic urticaria patients with the disorder of immune function in the body;and 18 beta glycyrrhizic acid glycosides treatment of serum IL-4 and IL-8,IL-17 and IL-22 reduced obviously,18 beta glycyrrhizin tips may through the influence of T helper cell related cytokines to play a role in treatment of chronic urticaria.关键词
慢性荨麻疹/18-β甘草酸苷/IL-4/IL-8/IL-17/IL-22Key words
chronic urticaria/glycyrrhizin/IL-4/IL-8/IL-17/IL-22分类
医药卫生
