摘要
Abstract
Objective To study the expression and biological significance of osteopontin(OPN)and CD44v6 in human malignant melanoma. Methods The distribution and expression of OPN and CD44v6 was detected in 16 malignant melanoma patients and in 12 patients with benign melanocytic nevi by immunohistochemistry. Results The positive expression rates of OPN and CD44v6 in malignant melanoma were 87.5%and 75%,respectively.The expression of OPN and CD44v6 was significantly higher in malignant melanoma than that in benign melanocytic nevi tissues(P<0.01)). There was a positive correlation between OPN and CD44v6(r=0.69,P<0.05).The positive rates of OPN and CD44v6 were associated with metastasis(P<0.05). Conclusion Overexpression of OPN and CD44v6 may contribute to the development and metastasis of malignant melanoma.关键词
骨桥蛋白/CD44v6/恶性黑素瘤/免疫组织化学Key words
osteopontin/CD44v6/melanoma malignant/immunohistochemistry分类
医药卫生
