中国免疫学杂志Issue(9)：1191-1194,4.DOI:10.3969/j.issn.1000-484X.2015.09.009
参附注射液对脑缺血再灌注损伤大鼠Nrf2信号通路的影响
Effect of Shenfu injection on Nrf2 signaling pathway in rats with cerebral ischemia reperfusion-induced brain injury
摘要
Abstract
Objective:To study the neuro-protective effects of Shenfu injection on Nrf 2 signaling pathway affected by cerebral ischemia reperfusion.Methods: A total of 68 adult male Sprague-Dawley rats were randomly divided into sham group , cerebral ischemia-reperfusion group,and(8 mg/kg)Shenfu injection treatment group.Shenfu injection was injected intraperitoneally in the rats after MCAO.Neurologic deficit was evaluated after 24 hours of reperfusion.All the rats were sacrificed after 24 h of ischemia-reoerfusion for biochemical analysis or Nissl staining.Results:Shenfu injection treatment significantly increased the expression of Nrf 2,HO-1 and NQO-1(P<0.05).Furthermore,Shenfu injection treatment significantly reduced the expression of cleaved -caspase-3 and attenuated neurological deficits after cerebral ischemia reperfusion ( P<0.05 ).Lastly, Shenfu injection could evidently alleviate the severity of neuronal degeneration ( P<0.05 ).Conclusion:Shenfu injection could confer neuroprotection after cerebral ischemia reperfusion through modulating the Nrf2 signaling pathway.关键词
脑缺血再灌注损伤/参附注射液/Nrf2/大鼠Key words
Cerebral ischemia reperfusion/Shenfu injection/Nrf2/Rat分类
医药卫生引用本文复制引用
江承平,吴碧华,王柏强,罗飞,何效平,王晓明,刘黎明..参附注射液对脑缺血再灌注损伤大鼠Nrf2信号通路的影响[J].中国免疫学杂志,2015,(9):1191-1194,4.基金项目
本文为四川省科技厅资助项目2010JY0094 （）
