中国免疫学杂志Issue(9)：1225-1228,1249,5.DOI:10.3969/j.issn.1000-484X.2015.09.017
新疆石河子地区汉族人群HLA-DPB1基因多态性与肺结核易感的相关性研究
HLA-DPB1 gene polymorphism and susceptibility to tuberculosis in Xinjiang Shihezi Han population:a case-control study
摘要
Abstract
Objective:In this study,we examined the HLA-DPB1 alleles in patients with tuberculosis,and health individuals attempt to investigate the association between the polymorphism of HLA-DPB1 gene and pulmonary tuberculosis in Han population in Shihezi area in Xinjiang uygur autonomous region of China.Methods:High-resolution typing of DPB1 was performed by the sequence-based typing ( SBT) method using the SBT-HLA-DPB1 generic DNA typing kit.Results:In the controls ,17 HLA-DPB1 alleles were ob-served,the HLA DPB1*0501 (28.1%) and HLA DPB1*0201(27.6%) frequency was significantly higher than other sites ,the first and second respectively.The frequency of HLA-DPB1* 0201 was observed significantly increased in patient group compared with control group ( P<0.05 );the frequency of HLA-DPB1* 0501 was observed significantly decreased in patient group compared with control group ( P<0.05 ).Conclusion: The gene frequencies of HLA-DPB1 in Xinjiang Shihezi Han population are roughly in consistence with other northern Chinese Han population;the HLA-DPB1*0201 may be the protective factor to pulmonary tuberculosis , and HLA-DPB1*0501 may be susceptible to pulmonary tuberculosis in Han population from the Xinjiang uygur autonomous region of China.关键词
肺结核/HLA-DPB1等位基因/多态性/易感性Key words
Pulmonary tuberculosis/HLA-DPB1 Alleles/Polymorphism/Susceptibility分类
医药卫生引用本文复制引用
卢丽君,吴江东,左维泽,张万江,章乐,吴芳..新疆石河子地区汉族人群HLA-DPB1基因多态性与肺结核易感的相关性研究[J].中国免疫学杂志,2015,(9):1225-1228,1249,5.基金项目
本文为国家自然科学基金资助项目（81160001）。 （）
