中国药房Issue(25)：3493-3495,3.DOI:10.6039/j.issn.1001-0408.2015.25.13
电解质对新生儿肠外营养液稳定性的影响
Effects of Electrolyte on the Stability of Neonatal Parenteral Nutrition
邓树荣 1张柳红 2闫丽娜 3金伟军1
作者信息
- 1. 暨南大学附属第一医院，广州 510630
- 2. 广州开发区医院，广州510730
- 3. 解放军第152中心医院，河南平顶山 467000
- 折叠
摘要
Abstract
OBJECTIVE:To study the effects of electrolyte on the stability of the neonatal parenteral nutrition. METHODS:Under room temperature(25 ℃),the neonatal parenteral nutrition containing only monovalent or bivalent ion electrolyte(10% So-dium chloride injection,10% Potassium chloride injection,25% Magnesium sulfate injection,and Calcium gluconate injection) and containing both monovalent and bivalent ion electrolyte were investigated by the change of appearance to determine the pH val-ue,insoluble particles and the size and distribution (polydispersity index,PDI) within 24 h. RESULTS:The pH of the nutrition with electrolyte was over 5 and also met the quality requirements;there were no precipitate,flocculation and discoloration in the appearance;the neonatal parenteral nutrition containing only monovalent ion electrolyte appeared a small amount of hanging wall phenomenon for 24 h,but did not appear demulsification phenomenon;the neonatal parenteral nutrition containing only bivalent ion electrolyte appeared a small amount of hanging wall phenomenon and demulsification phenomenon for 24 h;the neonatal paren-teral nutrition containing both monovalent and bivalent ion electrolyte appeared a small amount of hanging wall phenomenon and de-mulsification phenomenon for 12 h and the hanging wall phenomenon was more obvious for 24 h. Meanwhile,a size bigger than 5μm microns and particle size bigger than 25 μm microns of insoluble particles appeared,and both the average particle size and PDI value were higher than those in the previous two situations(P<0.05). CONCLUSIONS:As more and more monovalent and biva-lent ion electrolyte being added into the neonatal parenteral nutrition,especially divalent ion electrolyte,the stability of the neona-tal parenteral nutrition decreases,which behaves as a phenomenon that the size of grains and the number of insoluble particles in-crease.关键词
电解质/新生儿肠外营养液/稳定性/粒径/不溶性微粒数Key words
Electrolyte/Neonatal parenteral nutrition/Stability/Particle size/Insoluble particles分类
医药卫生引用本文复制引用
邓树荣,张柳红,闫丽娜,金伟军..电解质对新生儿肠外营养液稳定性的影响[J].中国药房,2015,(25):3493-3495,3.
