中国药房Issue(25)：3554-3556,3557,4.DOI:10.6039/j.issn.1001-0408.2015.25.33
白藜芦醇-泊洛沙姆188固体分散体的制备及其性能研究
Preparation and Properties of Resveratrol-poloxamer 188-solid Dispersion
摘要
Abstract
OBJECTIVE:To prepare Resveratrol-poloxamer 188-solid dispersion(RES-P188-SD)and study its dissolving char-acteristic in vitro and antibacterial activity. METHODS:With P188 as the carrier, solvent method was used to prepare RES-P188-SD. With the mass ratio of drug to carrier,melting temperature and mesh number as the observed factors,and solubility and yield of RES as the observed indexes,L9(34)orthogonal test was designed to optimize the preparation technology,and compre-hensive score of observed indexes were analyzed. The verification test was carried out. After RES-P188-SD was prepared by the op-timal technology,basket method was used to determine its dissolution rate and then its accumulative dissolution rate was calculat-ed,scanning electron microscopy to analyze phase characterization and cylinder-plate method to determine antibacterial activity. RE-SULTS:The optimal technology was as follows as the mass ratio of drug to carrier of 1∶10,melting temperature of 70 ℃ and mesh number of 80. For the sample prepared by the optimal technology,average solubility was 0.51 mg/ml (RSD=1.96%,n=3),average yield was 91%(RSD=0.64%,n=3),average 15 min accumulative dissolution rate was up to 83%(RSD=0.69%, n=3);the drug in amorphous form was homogenously distributed in the carrier;RES-P188-SD could inhibit Staphylococcus aure-us and Escherichia coli. CONCLUSIONS:The optimal technology is stable and feasible,by which RES-P188-SD has been pre-pared successfully,providing reference for increasing the solubility,dissolution rate and antibacterial activity of RES.关键词
白藜芦醇/泊洛沙姆188/固体分散体/溶解度/抑菌性Key words
Resveratrol/Poloxamer 188/Solid dispersion/Solubility/Antibacterial activity分类
医药卫生引用本文复制引用
任红暖,王晓丽,陈肖如,陈丽萍,周婷婷,高振珅,宋兴良..白藜芦醇-泊洛沙姆188固体分散体的制备及其性能研究[J].中国药房,2015,(25):3554-3556,3557,4.基金项目
本课题为大学生创新创业计划项目资助，项目编号为201410452021，指导教师为高振珅、宋兴良） （）
