中国药理学通报Issue(9)：1211-1215,5.DOI:10.3969/j.issn.1001-1978.2015.09.007
大黄酚对糖尿病脑病大鼠海马中 BDNF、iNOS 和氧化应激的影响
Effects of chrysophanol on BDNF and iNOS together with oxidative stress in rats with diabetes-associated cognitive decline
摘要
Abstract
Aim To assess the protective role of chry-sophanol in rats with diabetes-associated cognitive de-cline (DACD) and explore the potential molecular mechanisms.Methods The learning and memory performance was assessed by Morris water maze test;the activities of AChE,ChAT,iNOS and oxidative stress markers including CAT,SOD and GSH-PX in the hippocampus were detected using respective com-mercial kits.The level of BDNF was also measured with commercial ELISA kit.Results Chrysophanol significantly improved learning and memory functions in the diabetic groups.Additionally,the activities of AChE,BDNF also found to be evidently increased, while decreased activities of ChAT,iNOS,CAT,SOD and GSH-PX were observed in the hippocampus of dia-betic rats.Conclusions Collectively,chrysophanol has a protective role against DACD and this neuropro-tection is associated with increasing BDNF level.Chry-sophanol can also suppress the activities of iNOS, CAT,SOD and GSH-PX in diabetic rats.It is likely to be a novel therapeutic drug for the treatment of diabetic patients with cognitive deficits in clinical practice.关键词
大黄酚/糖尿病脑病/神经保护/海马/BDNF/iNOS/氧化应激Key words
chrysophanol/diabetes-associated cogni-tive decline/neuroprotection/hippocampus/BDNF/iNOS/oxidative stress分类
医药卫生引用本文复制引用
毛小元,李秋琪,周宏灏,刘昭前..大黄酚对糖尿病脑病大鼠海马中 BDNF、iNOS 和氧化应激的影响[J].中国药理学通报,2015,(9):1211-1215,5.基金项目
国家自然科学基金资助项目 （）
