中国药理学通报Issue(9)：1228-1232,1233,6.DOI:10.3969/j.issn.1001-1978.2015.09.010
白藜芦醇对大鼠脑缺血／再灌注损伤后星形胶质细胞活化的影响
Effects of resveratrol on astrocyte activation after cerebral ischemia/reperfusion injury in rats
摘要
Abstract
Aim To investigate the effect of resveratrol on astrocyte activation after cerebral ischemia/reperfusion injury in rats.Methods 45 male Sprague-Dawley rats were divided into sham,control and resveratrol groups, 15 rats in each group.Resveratrol or solvent was intra-peritoneally perfused into the rats for 7 consecutive days after 3h for MCA I /R.Cerebral infarction volume with TTC,neurological function score with Longa score, and pathological change with HE staining,the protein expressions of Caspase-3 with immunohistochemistry at 24h after MCA I /R were examined.The protein ex-pressions of GFAP and NeuN in penumbra were detec-ted with immunohistochemistry and immunofluores-cence at 14d after MCA I /R.Results Resveratrol treatment significantly improved the neurological func-tion score,decreased the infarct volume,reduced neu-ron loss,and inhibited the activation and proliferation of astrocytes,compared with the control group.Con-clusion Resveratrol can inhibit the excessive activa-tion of astrocytes,protect neurons in penumbra and im-prove neurological function.关键词
白藜芦醇/脑缺血/再灌注损伤/星形胶质细胞/神经元/活化Key words
resveratrol/cerebral ischemia/reperfusion injury/astrocyte/neuron/activation分类
医药卫生引用本文复制引用
余萍萍,王莉,唐凡人,周露玲,曾立,宋晓松,陈吉祥,杨琴..白藜芦醇对大鼠脑缺血／再灌注损伤后星形胶质细胞活化的影响[J].中国药理学通报,2015,(9):1228-1232,1233,6.基金项目
国家自然科学基金面上项目（No 81071119）；卫计委国家临床重点专科建设项目资金资助 （）
