中国药理学通报Issue(9)：1280-1285,1286,7.DOI:10.3969/j.issn.1001-1978.2015.09.020
拟黑多刺蚁醇提物抗抑郁作用研究
Antidepressive-like effect of alcoholic extract of Polyrhachis vicina Roger
摘要
Abstract
Aim To investigate the antidepressive-like effect of ethyl alcohol extract of Polyrhachis vicina Rog-er(EAPR),and its mechanism.Methods EAPR was prepared by ethanol extraction.Its anti-depressive effect was investigated by tail suspension test (TST) and forced swimming test (FST).Furthermore,repeated doses of reserpine was used for preparing the depres-sive rats.Results EAPR has definitely anti-depres-sive effect,as evidenced by the decreased immobility time in FST and TST at the doses of 8 and 4 g·kg -1 (P <0.05).In the repeated reserpine evoked depres-sive rats,EAPR antagonized the symptoms induced by monoamines depletion and attenuated the anhedonia, as manifested by reversed hypothermia,akinesia and sucrose consumption at the doses of 8 and 2 g·kg -1 (P <0.05,P <0.01).Neuro-chemical studies showed that AFPR significantly increased the concentration of monoamines,including 5-hydroxytryptamine (5-HT) and noradrenaline(NA)at the dose of 8 g·kg -1 (P <0.05),and had no effect on normal rats .Furthermore, EAPR increased the activity of superoxide dismutase (SOD)in serum,hippocampus and cerebral cortex at the dose of 8 g·kg -1 (P <0.05).Conclusion EA-PR possesses the definite antidep ressive properties, connected with the regulation of neurotransmitter me-tabolism and the nerve cells antioxidant effect.关键词
拟黑多刺蚁/抑郁/作用机制/5-羟色胺/去甲肾上腺素/超氧化物歧化酶Key words
Polyrhachis vicina Roger/depression/mechanism/5-hydroxytryptamine/noradrenaline/su-peroxide dismutase分类
医药卫生引用本文复制引用
韦桂宁,林霄,曾宪彪,韦宝伟,陈乃宏,楚世峰,苏华,何飞,苏启表,卢文杰,陆国寿,黄周锋,谭晓..拟黑多刺蚁醇提物抗抑郁作用研究[J].中国药理学通报,2015,(9):1280-1285,1286,7.基金项目
国家自然科学基金资助项目（No 81360653，81560663）；广西自然科学基金资助项目（No 2011GXNSFA018258）；广西中医药民族医药继承创新工程课题 （）
