中国医学创新Issue(25)：1-3,4,4.DOI:10.3969/j.issn.1674-4985.2015.25.001
妊娠期糖尿病患者和正常孕妇在不同孕周中血清及新生儿脐血中视黄醇结合蛋白4的含量变化
Levels of Retinol-Binding Protein 4 in Neonates Umbilical Blood and Serum of Gestational Diabetes Mellitus Patients and Normal Pregnant Women during Different Gestational Weeks
摘要
Abstract
Objective:To study the expression of retinol-binding protein 4 in neonates umbilical blood and serum of gestational diabetics and normal pregnant women during different gestational weeks in order to provide basis for the estimation and treatment of gestational diabetes mellitus(GDM).Method:Among the pregnant women who received antenatal care in our hospital from January 2013 to December 2013,50 pregnant women with GDM were selected as the experimental group,50 normal pregnant women were selected as the control group.The retinol-binding protein 4 levels in serum of neonates umbilical cord and pregnancy of 31 to 33 weeks and 37 to 41 weeks were detected through ELISA method.Result:The retinol-binding protein 4 was increased according with the increase of gestational weeks, the differences of it in different times were statistically significant(P<0.001). The retinol-binding protein 4 of the experimental group in different times was higher than that of the control group,the difference was statistically significant (P<0.001).The difference values in retinol-binding protein 4 of the two groups were increased with the time, the differences were statistically significant(P<0.001).The ranges of retinol-binding protein 4 in the experimental group were greater than those in the control group, the differences were statistically significant(P<0.001).The retinol-binding protein 4 of the experimental group had positive correlations with FBG,FINS and HOMA-IR(P<0.001). Conclusion:Retinol-binding protein 4 levels may use as the basis for the prediction and assessment of GDM and as the guidelines for the treatment of gestational diabetes mellitus.关键词
妊娠期糖尿病/脂肪因子/视黄醇结合蛋白4Key words
Gestational diabetes mellitus/Adipokines/Retinol binding protein 4引用本文复制引用
孙霞,韩淑娟,纪向虹,王茜..妊娠期糖尿病患者和正常孕妇在不同孕周中血清及新生儿脐血中视黄醇结合蛋白4的含量变化[J].中国医学创新,2015,(25):1-3,4,4.基金项目
青岛市市立医院资助项目 （）
