中国医学创新Issue(25)：4-7,4.DOI:10.3969/j.issn.1674-4985.2015.25.002
联合尿N-乙酰-β-D-氨基葡萄糖苷酶与尿/血渗透压比测定在糖尿病肾病早期诊断中的价值
The Value of Combined with Urinary N-acetyl-β-D-glucosaminidase and Urine to Blood Osmolality Ratio in Early Diagnosis of Diabetic Nephropathy
摘要
Abstract
Objective: To evaluate the value of combined with urine to blood osmolality ratio and urinary N-acetyl-β-D-glocosaminidase (NAG) in early diagnose of diabetic nephropathy.Method: A total of 150 patients with type 2 diabetes mellitus were divided into three groups including group A (UAER<20 µg/min, 65 cases), group B(20 µg/min≤UAER<200 µg/min, 54 cases), and group C (UAER≥200 µg/min, 31 cases). 30 healthy subjects were enrolled as the control group. The blood-urinary osmolality and urinary NAG were determined, which were compared between the three groups.Result: (1) Correlation analysis showed that urinary NAG was positively correlated with course, UAER, BUN, age (r=0.296,0.424,0.247,0.266,P<0.01), HbA1c, urine-glucose, and creatinine (r=0.217, 0.205,0.245,P<0.05). Urine to blood osmolality ratio was negatively correlated with disease course, UAER, serum creatinine, age (r=-0.259,-0.371,-0.252,-0.282,P<0.01), HbA1c (r=-0.227,P<0.05), but positively GFR (r=0.200,P<0.05). (2) There were significant differences between the three groups in urinary NAG and urine to blood osmolality ratio (P<0.05).Conclusion: Urinary NAG combined with urine to blood osmolality ratio contribute to complete assessment the renal tubular function, and is conducive to the early diagnosis of diabetic nephropathy.关键词
糖尿病肾病/N-乙酰-β-D-氨基葡萄糖苷酶/尿/血渗透压比值Key words
Diabetic nephropathy/N-acetyl-β-D-glocosaminidase/Urinary to blood osmolality ratio引用本文复制引用
柴学峰,王国君,朱宏伟,李华,王国萍..联合尿N-乙酰-β-D-氨基葡萄糖苷酶与尿/血渗透压比测定在糖尿病肾病早期诊断中的价值[J].中国医学创新,2015,(25):4-7,4.基金项目
包头市医药卫生科技计划项目 （）
