中国医学前沿杂志（电子版）Issue(7)：126-129,4.
培门冬酶对急性淋巴细胞白血病患儿肝脏毒性的临床研究
The hepatotoxicity of polyethylene glycol conjugated L-asparaginase with therapeutic dose for acute lymphoblastic leukemia in childhood
郝琎琎 1邱奕宁 1金润铭1
作者信息
- 1. 华中科技大学同济医学院附属协和医院 儿科，武汉430022
- 折叠
摘要
Abstract
ObjectiveTo study the hepatotoxicity of polyethylene glycol conjugated L-asparaginase (PEG-Asp) with therapeutic dose in children with acute lymphoblastic leukemia (ALL).MethodA study of 48 ALL children in department of pediatrics of our hospital from October 2012 to July 2014 was performed, and their hepatotoxicity were monitored, included the observation of treatment response and dynamic changes in hepatic function.Result28 cases of the 48 children had suffered liver function damage. Among them, 22 children with clinical manifestations, included digestive tract symptom, liver enlargement and jaundice. The liver function index serum γ-GT and total protein had no signiifcant changes before and after treatment with PEG-Asp; ALT had elevated in the ifrst week, and signiifcantly increased in the second week, and in the third week, it returned to normal level; AST and total bilirubin appeared slightly increased in the second week, and albumin at the second week showed mild to moderate decline, and all of the laboratory indexes can recover to normal level within three weeks.ConclusionDigestive tract symptom are the main performance in the ALL children which suffered hepatic toxicity by PEG-Asp the hepatic dysfunction is gently and transient and usually reversible. But the dynamic changes should be observed closely.关键词
肝脏毒性/急性淋巴细胞白血病/培门冬酶Key words
Hepatotoxicity/Acute lymphoblastic leukemia/Polyethylene glycol conjugated L-asparaginase引用本文复制引用
郝琎琎,邱奕宁,金润铭..培门冬酶对急性淋巴细胞白血病患儿肝脏毒性的临床研究[J].中国医学前沿杂志（电子版）,2015,(7):126-129,4.
