摘要
Abstract
Objective To discuss the clinical effect of risperidone combined with clozapine in the use of two kinds of drugs for the treatment of refractory schizophrenia.Methods 100 patients with refractory schizophrenia of our hospital was selected as the research object, randomly divided into observation group and control group,50 cases in each group,the cases in the observation group was treated by risperidone combined with clozapine,while the cases in the control group only received risperidone treatment,observation of 12 weeks,before entering the group,respectively treatment of 6 weeks and 12 weeks,the efficacy of treatment was assessed by the Brief Psychiatric Rating Scale (BPRS). And using the TESS to evaluate adverse reaction.ResultsIn the observation group,BPRS total score after 6 weeks and 12 weeks were significantly lower than the control group,the difference was statistically significant (P<0.05). TESS scores is similar between the two groups , it has no statistical significance (P>0.05).Conclusion For refractory schizophrenia,we may try to treat them with the combination of risperidone and clozapine,it is safety and effective,worthy of clinical popularization and application.关键词
利培酮/氯氮平/难治性精神分裂症Key words
Risperidone/Clozapine/Refractory schizophrenia分类
医药卫生
