中国卒中杂志Issue(9)：761-765,5.DOI:10.3969/j.issn.1673-5765.2015.09.008
手术与药物治疗对成年烟雾病患者认知功能的影响
Inlfuence of Cognitive Function in Surgical and Drug Treatment for Adult Patients with Moyamoya Disease
邸飞 1范震红 2李俊杰1
作者信息
- 1. 1100050 北京首都医科大学附属北京天坛医院神经外科
- 2. 首都医科大学附属北京天坛医院药剂科
- 折叠
摘要
Abstract
Objective To investigate the inlfuence of surgical and pharmacological therapies on the cognitive function of patients with adult moyamoya disease. Methods A total of 52 patients with adult moyamoya disease were included, and were divided into a surgical group and a control group according to their treatment plans. Patients in the control group were treated with conservative therapy using aspirin enteric-coated sustained release tablets, dextran 40, oxiracetam, and dexamethasone. Patients in the surgical group received surgical therapies (direct bypass operations and indirect bypass operations). The cognitive functions of patients in the two groups were assessed before treatments and 6 months after treatments to evaluate the improvement in patients’ cognitive functions. Results There was no significant difference in patients’ cognitive functions between the two groups before treatments. At 6-month follow-up, Montreal cognitive assessment(MoCA) of the patients showed that patients’ cognitive functions of the surgical group (t=2.092,P=0.009) and the control group (t=2.814,P=0.007) had improved signiifcantly compared to those before treatments, respectively. Assessments using mini-mental state examination(MMSE) showed significant improvement in the surgical group (t=2.706,P=0.005) while the control group had no signiifcant improvement. Comparison of the curative effects between the two groups showed that the rate of therapeutic effectiveness was higher in the surgical group than in the control group, which is statistically signiifcant (96.15%vs 84.62%,χ2=10.15,P<0.05). Conclusion Surgical therapy for moyamoya disease can better improve patients’ cognitive functions and clinical curative effects than pharmacological therapy.关键词
手术/烟雾病/认知功能Key words
Surgery/Moyamoya disease/Cognitive function引用本文复制引用
邸飞,范震红,李俊杰..手术与药物治疗对成年烟雾病患者认知功能的影响[J].中国卒中杂志,2015,(9):761-765,5.
