中国卒中杂志Issue(9)：771-777,7.DOI:10.3969/j.issn.1673-5765.2015.09.010
小胶质细胞激活介导非特异性炎症在血管性认知障碍白质脱髓鞘损伤机制中的研究进展
Progress of Researches on the Mechanism of the Role of Nonspecific Inflammation Mediatedby Microglia Activation in the White Matter Demyelination of Vascular Cognitive Impairment
李海龙 1毕晓莹1
作者信息
- 1. 200433 上海第二军医大学附属长海医院神经内科
- 折叠
摘要
Abstract
Microglia as the main immune surveillance cell in central nervous system can cause acute or chronic cerebral ischemic injury via mediating inflammation and oxidative stress and releasing varieties of products with neurotoxicity, which could even cause the death of neurons and other glial cells. White matter demyelinatingis the feature of vascular cognitive impairment, marked by magnetic resonance imaging of brain, which is a disease caused by chronic cerebral ischemic damage. We reviewed researches on the mechanism of the role of ischemic nonspecific inflammation in the white matter damage mediated by microglia activation, in order to provide reference and help for further mechanism studies.关键词
小胶质细胞/炎症/血管性认知障碍/脑白质损伤/少突胶质细胞Key words
Microglia/Inflammation/Vascular cognitive impairment/White matter lesion/Oligodendrocyte引用本文复制引用
李海龙,毕晓莹..小胶质细胞激活介导非特异性炎症在血管性认知障碍白质脱髓鞘损伤机制中的研究进展[J].中国卒中杂志,2015,(9):771-777,7.
