肿瘤药学Issue(4)：293-297,5.DOI:10.3969/j.issn.2095-1264.2015.04.12
FOLFOX4方案新辅助化疗对老年局限性低位直肠癌的疗效
The Clinical Effects of Neoadjuvant Chemotherapy for Elderly Patients with Local Lower Rectal Cancer
曾红波 1黄波 1李兵峰 1高风华 1刘庆华 1陈凯 1杨文伦1
作者信息
- 1. 天门市第二人民医院外科，湖北 天门，431700
- 折叠
摘要
Abstract
Objective To observe the clinical efficency and safety of neoadjuvant chemotherapy with FOLFOX4 regime for elderly patients with local lower colorectal cancer. Methods A total of 56 elderly patients with local lower colorectal cancer admitted in our hospital were selected and randomly divided into the observation group and control group, 28 cases in each group. The observation group was treated with FOLFOX4 regime neoadjuvant chemotherapy before surgery, while the control group underwent directly surgical treatment without chemotherapy. Then the tumor progression were observed and compared between the two groups, and the sphincter preservation, short and long-term efficeny and the incidence of adverse reactions were analyzed. Results The total effective rate of neoadjuvant chemotherapy in observation group was 65.38% (17/26), and the tumor stages decreased after chemotherapy. The sphincter preservation rates of observation group and control group were 92.31% and 64.29% respectively, which was significantly higher in the observation group(P<0.05). After operation, the 1-, 2-, 3-year survival rates were 92.31%, 66.67% and 44.44% respectively in the observation group, and were respectively 67.86%, 57.89% and 41.67% in the control group. No conspicuous difference was found between the two groups (P>0.05). The main adverse reactions in observation group included nausea, vomit, neurotoxicity and hemameba decline. Two cases in the obser-vation group terminated chemotherapy because of intolerance. Conclusion The FOLFOX4 regime neoadjuvant chemotherapy could significantly reduce cancer stage and improve the sphincter preservation rate in the treatment of elderly patients with local lower colorectal cancer.关键词
直肠癌/新辅助化疗/保肛率Key words
Colorectal cancer/Neoadjuvant chemotherapy/Sphincter preservation rate分类
医药卫生引用本文复制引用
曾红波,黄波,李兵峰,高风华,刘庆华,陈凯,杨文伦..FOLFOX4方案新辅助化疗对老年局限性低位直肠癌的疗效[J].肿瘤药学,2015,(4):293-297,5.
