安徽工程大学学报Issue(4)：17-19,3.
粘杆菌素流加补糖发酵工艺研究
Study on fermentation process of colistin by flow feed in sugar
李为全 1王洲2
作者信息
- 1. 安徽省皖北药业股份有限公司，安徽 宿州 234000
- 2. 安徽工程大学 生物与化学工程学院，安徽 芜湖 241000
- 折叠
摘要
Abstract
The old fermentation process of colistin has the disadvantages of short fermentation period and low fermentation unit.This paper developed a new sugar supplement test for colistin and studied the fed sugar fermentation process of colistin.By using fed glucose fermentation process,the inhibition of colistin synthesis rate due to the high glucose concentration can be relieved.Combined with the optimization of fermentation inoculum and culture temperature parameter,the colistin fermentation unit can go up from 1 10 000 U/mL to 520 000 U/mL.And this technology has been successfully applied to large-scale pro-duction.关键词
粘杆菌素/流加补料/发酵Key words
colistin/flow feeding/fermentation分类
生物科学引用本文复制引用
李为全,王洲..粘杆菌素流加补糖发酵工艺研究[J].安徽工程大学学报,2015,(4):17-19,3.
