北京中医药大学学报Issue(7)：444-446,3.DOI:10.3969/j.issn.1006-2157.2015.07.003
试论“风药”止血作用及其机理
Hemostatic effect and mechanism of wind-dispelling Chinese medicinal herbs
摘要
Abstract
Wind-dispelling Chinese medicinal herbs were widely used in syndrom of bleeding due to the effect of hemostasis.Based on the experiences of clinical practice,the ancient TCM physicians summarized that bleeding was caused by“wind pathogen damaged blood”,that is to say,wind pathogen,tending to move and change,blowed the blood to flow outside the channels.While modern medical literature showed that inducible nitric oxide synthase (iNOS)was the key factor closely related to syndrom of bleeding,the anticoagulant effect of iNOS worked mostly through producing a large amount of nitric oxide(NO)and promoting expression of cyclooxygenase-2(COX-2).Wind-dispelling medicine could down-regulate gene expression of iNOS at dif-ferent steps to inhibite the production of NO and expression of COX-2,so as to promote platelet adhesion and aggregation and vasoconstriction.The hemostatic mechanism of wind-dispelling medicine is potentially related to the anti-inflammatory effects reducing inflammatory cytokines.关键词
风药/止血/一氧化氮合酶/环氧合酶-2Key words
wind-dispelling Chinese medicinal herbs/hemostasis/iNOS/COX-2分类
医药卫生引用本文复制引用
胡红林,杨桢,鲁赛,高琳..试论“风药”止血作用及其机理[J].北京中医药大学学报,2015,(7):444-446,3.基金项目
北京中医药大学自主课题项目 （）
