Journal of Changshu Institute of Technology2015，Vol.29Issue(4)：8-14,7.
SIRT1基因的表达调控及对动物脂类代谢的功能
Expression Regulation and Functions of Lipid Metabolism of SIRT1 Gene
摘要
Abstract
SIRT1, a member of the Sirtuin family, is a kind of NAD+-dependent histone deacetylase. SIRT1 in?teracts with non-histone proteins and histone such as p53, Ku70, FOXOs, PGC-1A, p300 as well as H1, H3, H4 to exert different functions. SIRT1 gene performs the regulation of glucose and lipid metabolism in the liver, fat, muscle, pancreatic and brain and other organs. SIRT1 is an important regulator of lipid homeostasis factor, and also plays a role in the oxidation of fatty acids. Expression and activity of SIRT1 will be regulated at a tran?scriptional, post-transcriptional and post-translational level respectively, and gene expression regulation and roles for lipid metabolism of sirt1 in animals will be reviewed in this paper.关键词
Sirtuin家族/SIRT1基因/脂类代谢/表达调控Key words
Sirtuin family/SIRT1 gene/lipid metabolism/expression regulation of gene分类
生物科学引用本文复制引用
邵芳,郁建锋,张燕萍,顾志良..SIRT1基因的表达调控及对动物脂类代谢的功能[J].Journal of Changshu Institute of Technology,2015,29(4):8-14,7.基金项目
国家自然科学基金"鸡SIRT1基因的表达调控及其对肝脏脂类代谢的功能研究"(31472091) （31472091）
江苏省自然科学基金"MicroRNA调控鸡SIRT1基因表达的分子机理研究"(SBK2015021516) （SBK2015021516）
苏州市产业技术创新专项(应用基础研究-农业)项目"MicroRNA调控鸡SIRT1基因表达的研究"(SYN201516) （应用基础研究-农业）
