南方医科大学学报2015，Vol.35Issue(8)：1180-1183,4.
三叉神经痛患者脑灰质结构的变化:一项基于体素的形态学测量
Structural changes in the gray matter in patients with trigeminal neuralgia:a voxel-based morphometric study
摘要
Abstract
Objective To investigate the changes in whole brain gray matter volume in patients with trigeminal neuralgia using voxel-based morphometry (VBM). Methods Twenty-eight patients with trigeminal neuralgia and 28 healthy controls underwent magnetic resonance imaging with a Philips 1.5T MRI scanner. VBM was used to compare the structural differences in the whole brain gray matter between the two groups based on the DARTEL after data preprocessing with SPM8 software package. Results Compared with the healthy controls, the patients with trigeminal neuralgia presented with decreased gray matter volume in several brain regions including the bilateral middle temporal gyrus, bilateral superior/middle frontal gyrus, left pre-/post-central gyrus, right fusiform and anterior cingulate gyrus. Conclusions Patients with trigeminal neuralgia had abnormal gray matter volume in some brain regions associated with perception and processing of pain sensation. These changes may provide clues for further exploration of the neuropathogenic basis of trigeminal neuralgia.关键词
三叉神经痛/灰质体积/VBM/磁共振成像Key words
trigeminal neuralgia/gray matter volume/voxel-based morphometry/magnetic resonance imaging引用本文复制引用
颜剑豪,李盟,汪天悦,詹文峰,江桂华..三叉神经痛患者脑灰质结构的变化:一项基于体素的形态学测量[J].南方医科大学学报,2015,35(8):1180-1183,4.基金项目
2014年广东省医学科研基金(A2014157) （A2014157）
