国际老年医学杂志Issue(5)：213-216,4.DOI:10.3969/j.issn.1674-7593.2015.05.007
Dermol与N-cadherin、 E-cadherin在喉鳞状细胞癌组织中的表达及相关性
Study on the Expression of Dermol, N-cadherin and E-cadherin in Laryngeal Carcinoma
杨文婧 1陈英 1赵瑞力 2贾国章1
作者信息
- 1. 河北省沧州市人民医院耳鼻喉科，沧州 061600 中国
- 2. 河北医科大学第四医院，石家庄 050000 中国
- 折叠
摘要
Abstract
OBJECTIVE: To investigate the expression and clinical significances of Dermol, N-cadherin and E-cadherin in la-ryngeal squamous cell carcinoma ( LSCC) . METHODS: The expression of Dermol, N-cadherin and E-cadherin were detected by immunohistochemistry S-P method in the tissue of 48 patients with LSCC and the tissue in 30 patients with tumor-adjacent normal. The relationship between three factors and clinical pathological features of LSCC was investigated. RESULTS: There were statistically significant in the differences of the positive rate of Dermol, N-cadherin and E-cadherin in LSCC and tumor-adjacent normal ( P<0. 01); There were statistically significant in the positive expression rate of Dermol, N-cadherin and E-cadherin in lympha node metastasis, clinical stage in LSCC (P<0. 01). There was no statistically significant difference between the different age groups (P>0. 05). The positive expression of Dermol was negatively related to that of E-cadherin ( r = -0. 344, P =0. 034). CONCLU-SION: Dermol, N-cadherin and E-cadherin play an important role in the occurrence, degree of differentiation, infiltration and metastasis of laryngeal squamous cell carcinoma. The synergistic effect of Dermol, N -cadherin and E -cadherin may have some effects on the infiltration and metastasis of laryngeal carcinoma.关键词
喉鳞状细胞癌/Dermol/N-cadherin/E-cadherin/免疫组化Key words
Laryngeal squamous cell carcinoma(LSCC)/Dermol/N-cadherin/E-cadherin/Immunohistochemistry(IHC)引用本文复制引用
杨文婧,陈英,赵瑞力,贾国章..Dermol与N-cadherin、 E-cadherin在喉鳞状细胞癌组织中的表达及相关性[J].国际老年医学杂志,2015,(5):213-216,4.
