摘要
Abstract
Objective To study the application value of metformin in therapy for gestational diabetes.Methods According to random number table method, 150 cases of gestational diabetes were randomly divided into metformin group ( only metformin therapy after diagnosed) and insulin group ( insulin therapy after diagnosed) with 75 cases in each group.Patients in metformin group not meeting the standard of blood glucose were given insuline together, and they were enrolled in combination group (31 cases).The blood sugar control level and pregnancy outcomes of three groups after treatment were compared.Results The fasting blood glucose (FBG), 2h postprandial blood glucose (2hPBG) and glycosylated hemoglobin (HbA1c) were not statistically different among three groups (all P>0.05).There was no statistical difference in gestational age and the incidence of gestational hypertension and eclampsism among three groups ( all P>0.05).The vaginal birth rate in metformin group (34.09%) was significantly lower than in insulin group (57.33%) and in combination group (58.06%) (χ2 value was 5.996 and 4.242, respectively, both P<0.05), but there was no significant difference between insulin group and combination group (P>0.05).There were no statistical differences in fetal survival rate, rate of jaundice, transient tachypnea (TTN) rate and the rate of respiratory distress syndrome (RDS) among three groups (all P>0.05).The rate of birth weight larger than gestational age ( LGA) , the rate of birth weight smaller than gestational age ( SGA) and the incidence of hypoglycemia in metformin group (4.55%, 6.82%, 4.55%) and combination group (3.23%, 6.45%, 6.45%) were lower than those in insulin group (20.00%, 22.67%, 21.33%) (χ2 =9.121,P=0.010;χ2 =7.672,P=0.022;χ2 =8.365,P=0.015), but there was no statistical difference between metformin group and combination group (P>0.05).Conclusion For patients with gestational diabetes, controlling blood sugar by metformin can effectively improve the birth outcomes.关键词
二甲双胍/胰岛素/妊娠期糖尿病/分娩结局Key words
metformin/insulin/gestational diabetes/delivery outcomes分类
医药卫生
