中国妇幼健康研究2015，Vol.26Issue(4)：760-762,765,4.DOI:10.3969/j.issn.1673-5293.2015.04.035
IVF-ET术后7 天血浆 D-二聚体水平与妊娠结局的相关性
Correlation between plasma D-dimer level at 7 days after IVF-ET and clinical outcomes
张莉莉 1石馨 1张学红 1何晓霞1
作者信息
- 1. 兰州大学第一医院生殖医学专科医院,甘肃兰州730000
- 折叠
摘要
Abstract
Objective To analyze the correlation between plasma D-dimer level at 7 days after in vitro fertilization-embryo transfer ( IVF-ET) and clinical outcomes.Methods From February to April in 2014 totally 102 cycles of fresh embryo transfer and 51 cycles of frozen thawed embryo transfer were selected from patients undergoing IVF-ET in Reproductive Medicine Hospital of First Hospital of Lanzhou University.Seven days after IVF-ET, blood was collected to test plasma D-dimer level to conduct statistical analysis on the correlation between D-dimer level and clinical outcomes.Results The D-dimer level in the cycles of fresh embryo transfer was significantly higher than that in those of frozen thawed embryo transfer (t=-8.031,P<0.01), but there was no significant difference in clinical pregnancy rate, implantation rate and early abortion rate ( all P>0.05 ) .There was no significant difference between pregnant group and non-pregnant group in fresh embryo transfer cycle in D-dimer level (P>0.05), so was between pregnant group and non-pregnant group in frozen thawed embryo transfer cycle in D-dimer level (P>0.05).D-dimer level of the cycle of fresh embryo transfer was divided by the median of 0.678μg/mL.The groups with lower and higher value were not significantly different in clinical pregnancy rate (56.86%vs 50.98%,P>0.05) and implantation rate (42.31%vs 33.96%, P>0.05), but they were obviously different in early abortion rate (3.45% vs 23.08%,χ2 =4.755,P<0.05).In the cycle of fresh embryo transfer, D-dimer level was significantly correlated with E2 level (r=0.513,P<0.01) and number of retrieved oocytes ( r =0.395, P <0.01 ) on HCG day.Conclusion In the cycle of fresh embryo transfer, the superovulation leads to the rise of serum estrogen and plasma D-dimer, hypercoagulable state, hyperfibrinolysis and the increase of abortion rate resulting from the negative influence on embryonic development.关键词
体外受精-胚胎移植/D-二聚体/凝血/流产Key words
in vitro fertilization-embryo transfer( IVF-ET)/D-dimer/coagulation/abortion分类
医药卫生引用本文复制引用
张莉莉,石馨,张学红,何晓霞..IVF-ET术后7 天血浆 D-二聚体水平与妊娠结局的相关性[J].中国妇幼健康研究,2015,26(4):760-762,765,4.
