化工学报2015，Vol.66Issue(9)：3271-3278,8.DOI:10.11949/j.issn.0438-1157.20150904
面向清洁生产的制药结晶
Clean production of pharmaceutical crystallization
摘要
Abstract
Pharmaceutical industry has been listed as one of the serious pollution industries in China. As the important and necessary part of pharmaceutical industry, crystallization technology should be optimized and updated to meet the clean production requirement. The pollution and waste caused by crystallization include toxic solvent applied, VOC emission, waste of mother liquor, bad properties of crystal product, and out-dated batch operation, etc. In face of these problems, the design methods and technology of clean production of pharmaceutical crystallization are reviewed and summarized. (a) Green crystallization. The solvent should be clean and effective. Single type of solvent and little consumption should be considered. Reduce the waste (gas, liquid and solid) emission by increasing crystal yield. Crystalline mother liquor and by-products should be reused and recycled. (b) Crystal engineering. Simplify the processes of filtering, washing, drying and tableting by optimizing crystal shape and interfacial properties. Solvates should be avoided to reduce the VOC emission. (c) Continuous crystallization. Compared with batch operation, novel continuous crystallization technology takes more advantages. (d) Intelligent device. Crystallization device should be optimized based on fluid dynamics to the benefit of crystal nucleation and growth. Integration of devices could reduce materials and energy consumption.关键词
清洁生产/制药/结晶/环境/废物处理/回收/产品工程Key words
clean production/pharmacy/crystallization/environment/waste treatment/recycle/product engineering分类
数理科学引用本文复制引用
龚俊波,陈明洋,黄翠,秦宇佳,尹秋响,王静康..面向清洁生产的制药结晶[J].化工学报,2015,66(9):3271-3278,8.基金项目
国家自然科学基金项目(21176173,21376164) （21176173,21376164）
国家高技术研究发展计划项目(2012AA021202).supported by the National Natural Science Foundation of China (21176173, 21376164) and the National High Technology Research and Development Program of China (2012AA021202). （2012AA021202）
