吉林中医药Issue(9)：938-941,4.DOI:10.13463/j.cnki.jlzyy.2015.09.022
木犀草素直肠保留灌肠对哮喘模型大鼠幼鼠干扰素－γ及白细胞介素－4的影响
Retention Enama treatment with Luteolin suppresses interferon gamma and interleukin 4 Levels in asthma mice model
摘要
Abstract
Objective To explore the influence of luteolin retention enema on interferon rats serum in rat asthma model of gamma (IFN-gamma) and interleukin 4 (IL-4) .Methods The 80 male and female SD rats were divided into blank group , model group ,gavage group ,retention enema group ,with 20 rats in each group .IFN-gamma and IL-4 content in serum were tested by method of ELISA .Rats in the lung tissue of rat asthma model change were observed under the microscope .Results Compared with the model group ,clysis group and the oral group could significantly increase the content of serum gamma IFN-in bronchial asthma rats ,and decreased the content of IL-4 .Significant differences ( P<0 .01 ) .Enema group and oral group histopathological observation of lung tissue infiltration is reduced ,the smooth muscle wall thickness reduction ,reduced tissue edema and congestion phenomenon .Conclusion Luteolin retention enema can reduce asthma in young rats serum IL-4 and IFN-content increased gamma .关键词
木犀草素/哮喘/白细胞介素4/干扰素-γ/保留灌肠/大鼠幼鼠Key words
Luteolin/asthma/IF-4/INF-γ/retention enama/mice分类
医药卫生引用本文复制引用
洪丽军,魏广州,陈祖仁,刘克新,张永政,王芳,王丛礼..木犀草素直肠保留灌肠对哮喘模型大鼠幼鼠干扰素－γ及白细胞介素－4的影响[J].吉林中医药,2015,(9):938-941,4.基金项目
黑龙江省卫生计生委科研课题（2014－084）。 （）
