检验医学与临床Issue(17)：2494-2496,2499,4.DOI:10.3969/j.issn.1672-9455.2015.17.005
二丙酸倍氯米松和糖皮质激素类药物灌肠治疗溃疡性结肠炎的疗效对比分析
Comparison of effect of enema of beclomethasone dipropionate and glucocorticoid drugs in treating ulcerative colitis
摘要
Abstract
Objective To compare the effect of enema of beclomethasone dipropionat(BDP) and glucocorticoid drugs in treating ulcerative colitis(UC) and its influencing factors .Methods 80 cases of UC in our hospital from March 2010 to June 2013 were selected as the research subjects ,and randomly divided into the conventional therapy group and the BDP treatment group according to the different treatment modes ,40 cases in each group .The clinical curative effects were compared between the two groups and the influencing factors were analyzed by Logistic multiva‐riate analysis .Results In the conventional therapy group after treatment ,12 cases were significantly effective and 16 cases were effective with the total effective rate of 70 .00% (28/40) ,while the total effective rate in the BDP treat‐ment group was 90 .00% (36/40) ,which was significantly higher than that in the conventional therapy group (P<0 .05);the multivariate Logistic regression analysis results showed that ,C‐reactive protein (OR=3 .81 ,P=0 .002) , platelet (OR=2 .01 ,P=0 .031) ,adverse drug reactions(OR= 2 .34 ,P=0 .017) and severe type (OR= 2 .54 ,P=0 .014) were the risk factors affecting the therapeutic effect in the conventional therapy group;severe type (OR=3 .11 ,P=0 .025) and C‐reactive protein(OR=2 .86 ,P=0 .004) were the risk factors in the BDP treatment group . Conclusion The effect of BDP in treating UC is obviously superior to the traditional glucocorticoid drugs ,and the main factors affecting effect are the severity of disease and C‐reaction protein level .关键词
二丙酸倍氯米松/糖皮质激素/溃疡性结肠炎/影响因素Key words
beclomethasone dipropionate/glucocorticoid/ulcerative colitis/influencing factors引用本文复制引用
董治华,隋典朋,王娜..二丙酸倍氯米松和糖皮质激素类药物灌肠治疗溃疡性结肠炎的疗效对比分析[J].检验医学与临床,2015,(17):2494-2496,2499,4.基金项目
国家卫生部资助项目（201202006-08）。 （）
