检验医学与临床Issue(17)：2540-2542,3.DOI:10.3969/j.issn.1672-9455.2015.17.023
原发性胆汁性肝硬化血清学抗体与戊型肝炎病毒抗体间的相关性分析
Correlation between serological antibody and hepatitis E virus antibody in primary biliary cirrhosis
邢雪梅 1李艳琴 1沈钢 1张军 1祝力琦1
作者信息
- 1. 西安交通大学医学院附属3201医院检验科，陕西汉中 723000
- 折叠
摘要
Abstract
Objective To retrospective study the correlation between serological antibody and hepatitis E virus (HEV) antibody in 127 cases of primary biliary cirrhosis (PBC) .Methods 127 cases of single or multiple PBC relat‐ed autoantibody positive serum samples ,including anti‐mitochondrial antibodies‐M2 (AMA‐M2) ,anti‐BCOADC‐E2 PDC‐E2 OGDC‐E2(M2‐3E/BPO) ,anti‐sp100 antibodies (anti‐sp100) ,anti‐gp210 antibodies (anti‐gp210) ,anti‐cen‐tromere‐associated proteins B (CENP B) ,were detected the IgG and IgM antibody of HEV by ELISA .Meanwhile 93 cases of systemic lupus erythematosus(SLE) ,92 cases of rheumatoid arthritis(RA) and 122 healthy adult serum sim‐ples were selected as control group for detecting HEV‐IgG/IgM antibody .Results The seroprevalence of HEV‐IgG antibody in the PBC group ,healthy adults control group ,SLE and RA groups were 55 .9% ,27 .0% ,23 .7% and 40 .2% respectively .The statistically significant difference between PBC group and other three groups was noticed (P<0 .05) .It demonstrated no significant difference between PBC related single‐antibody positive group and multi‐antibody positive group(χ2 =0 .319 ,P>0 .05) .No sex difference was found (χ2 =0 .281 ,P>0 .05) .Conclusion The high seroprevalence of HEV‐IgG antibody exists in the PRB related autoantibody positive serum .There may be mutual interference between PBC related autoantibody and HEV‐IgG antibody .关键词
原发性胆汁性肝硬化/自身抗体/戊型肝炎病毒抗体Key words
primary biliary cirrhosis/autoantibody/hepatitis E virus antibody引用本文复制引用
邢雪梅,李艳琴,沈钢,张军,祝力琦..原发性胆汁性肝硬化血清学抗体与戊型肝炎病毒抗体间的相关性分析[J].检验医学与临床,2015,(17):2540-2542,3.
