检验医学与临床Issue(18)：2741-2742,2745,3.DOI:10.3969/j.issn.1672-9455.2015.18.037
住院患者分离的纹带棒状杆菌耐药性及同源性研究
Study on drug resistance and homology of Corynebacterium striatum isolated from inpatients
摘要
Abstract
Objective To analyze the drug resistance and homology of Corynebacterium striatum isolated from inpatients .Methods 58 inpatients in our hospital from 2013 October to 2014 April were selected .58 strains Coryne‐bacterium striatum were isolated from different parts .The in vitro drug susceptibility test was performed by using the broth microdilution method .The surround environment in the patients with Corynebacterium striatum positive were sampled by saline cotton swab .The isolated Corynebacterium striatum was performed the in vitro drug susceptibility test ;58 strains of Corynebacterium striatum were performed the molecular typing by using the pulsed field gel elec‐trophoresis (PFGE) .Results Corynebacterium striatum aggregation was distributed in December 2013 ,January , February and March 2014 .The results of drug susceptibility test showed that the minimal inhibitory concentrations (MIC) of the 5 kinds of antibacterial drugs ,tetracycline ,erythromycin ,clindamycin ,ciprofloxacin and penicillin ,were more than or equal to 64 μg/mL ;MIC of vancomycin ,rifampicin and gentamicin all were 0 .5 μg/mL ;only 1 isolated strain of Corynebacterium striatum was sensitive to all antibacterial drugs except for clindamycin .The pulsed field gel electrophoresis typing results showed that 50 strains of Corynebacterium striatum were divided into 7 different geno‐types ,in which 0002 genotype and 0006 genotype were predominant type .Corynebacterium striatum isolated from the patients in the same ward during the corresponding period had high homology .The environmental sampling results showed that the isolation positive rate of Corynebacterium striatum reached 43 .48% (10/23) .Conclusion Coryne‐bacterium striatum isolated from inpatients presents multi‐drug resistance ,and which isolated from different in pa‐tients has extremely high homology .关键词
棒状杆菌属/耐药性/同源性/分子分型Key words
Corynebacterium/drug resistance/homology/molecular typing引用本文复制引用
邓洪均..住院患者分离的纹带棒状杆菌耐药性及同源性研究[J].检验医学与临床,2015,(18):2741-2742,2745,3.
