摘要
Abstract
Objective To analyze the identification value of cerebrospinal fluid(CSF) and serum procalcitonin (PCT ) ,neutrophil CD64 and C‐reactive protein(CRP) in children meningitis infected by different pathogens and to explore the feasibility of three methods for monitoring the treatment and prognosis .Methods 123 children cases of meningitis ,including purulent meningitis(PM group ,65 cases) and viral meningitis(VM group58 cases) according to the differential diagnosis .At the same time ,60 children patients with non‐central nervous system infection were se‐lected as the healthy control group (control group) .Serum and CSF were sampled for detecting PCT ,neutrophil CD64 and CRP within 24 ho after admission and after a time of treatment .The change and positive rate of these 3 in‐dexes in the acute stage and recovery stage were analyzed .Results The detection results of these 3 indexes in the early onset had obvious identification significance in the PM group and the VM group ,the differences among groups were statistically significant (P< 0 .05) ;in the identification detection in the acute and recovery stages of various groups ,the identification difference of CRP between the PM group and the VM group had statistical significance(P<0 .05) ;acute phase and recovery phase differential detection ,CRP has statistical difference between the PM group and disease group(P< 0 .05) ,the difference of CD64 had statistical significance for the detection of the PM group(P <0 .05) ,but the expression level of the VM group group had no statistical difference compared with the control group ;in the comparison of the positive rate in the PM group and the VM group ,the difference of PCT detection had statis‐tical significance ,while CRP had no significant difference .Conclusion PCT is effective for the observation before treatment and prognosis detection ,has an important reference value in the differentiation diagnosis of PM and VM ,is better than the CRP detection result .CD64 has important significance for the detection of PM in children ,can be used as an effective index in clinical promoting use .关键词
病毒性脑膜炎/化脓性脑膜炎/降钙素原/C反应蛋白/中性粒细胞CD64Key words
viral meningitis/purulent meningitis/procalcitonin/C-reactive protein/neutrophil CD64
