四川医学2015，Vol.36Issue(8)：1073-1077,5.DOI:10.16252/j.cnki.issn1004-0501-2015.08.003
新生儿败血症病原菌及耐药性分析
The Analysis of Aetiology and Resistance of Neonatal Sepsis
赵静 1张鸽 1杨晓燕 1唐军 1石晶1
作者信息
- 1. 四川大学华西第二医院儿科,四川 成都610041
- 折叠
摘要
Abstract
Objective To investigat the composition, distribution and drug resistance characteristics of the pathogens iso-lated from newborns with sepsis in our hospital in recent 5 years so as to provide evidence for clinical treatment. Methods A ret-rospective study of neonatal sepsis was conducted in West China Second University Hospital from January 1, 2008 to April 30, 2015. The results of pathogen and drug resistance were anylized. Results 182 stains were detected in recent five years. Esche-richia coli ( 43/182, 23. 63%), Klebsiella pneumoniae ( 37/182, 20. 33%), Coagulase-Negative staphylococci ( 31/182, 17. 03%), fungi (16/182,8. 79%)and Staphylococcus aureus(15/182,8. 24%) were the five most common pathogens. Esche-richia coli, Klebsiella pneumoniae and Coagulase-Negative staphylococci were the main pathogens causing early-onset of sepsis, while Klebsiella pneumoniae, Coagulase-Negative staphylococci and fungi were the main pathogens for late-onset sepsis. The drug resistance of Gram-negative bacilli to ampicillin was above 95%. Extended-Spectrumβ-Lactamases positive bacteria were the main pathogens of late-onset sepsis, and they demonstrated a strong resistance to Cefazolin and ceftazidime ( above 60%) . They didn't show any resistance to imipenem, cefotan and amikacin. The drug resistance of Staphylococcus to penicillin were more than 80%. We didn't found any Gram-positve bacteria resistant to vancomycin. The fungi demonstrated about 40% resistance to triazole anti-fungal drugs. No fungi were resistance to amphotericin B and 5-fluorocytosine. Conclusion Escherichia coli, pneumonia Kleb-siella and coagulase negative staphylococci were the main pathogens causing neonatal sespis in rencent 5 years in our hospital. Pathogens and bacteria drug resistance were difference in Early-onset and late-onset sepsis. Regular monitoring of pathogens and drug resistance could be helpful for clinical rational use of antibiotics in neonatal sepsis.关键词
新生儿/败血症/病原菌/耐药性Key words
neonates/sepsis/pathogen/drug resistance分类
医药卫生引用本文复制引用
赵静,张鸽,杨晓燕,唐军,石晶..新生儿败血症病原菌及耐药性分析[J].四川医学,2015,36(8):1073-1077,5.
