四川医学Issue(9)：1205-1208,4.DOI:10.16252/j.cnki.issn1004-0501-2015.09.001
异氟烷麻醉下肾切除术对老年大鼠学习记忆能力的影响
Affect of Unilateral Nephrectomy under Isoflurane Anesthesia on Learning and Memory in Aged Rats
摘要
Abstract
Objective To investigate the affect of unilateral nephrectomy under isoflurane anesthesia on learning and memory in aged rats. Methods 48 healthy aged male rats were randomly assigned into two groups:40% oxygen inhalation for three hours only and left nephrectomy under 3-hour 2% isoflurane anesthesia. After treatment, learning and memory ability was assessed daily by using Y maze for one week(n=12). Serum level of interleukin-6 (IL-6) was determined at 1 and 7 days after treatment( n=6/subgroup) . Results At the 3 and 5 day after treatment, number of Y maze correct reactions ofrats enduring sur-gery under anesthesia was significantly less than thoseof rats in control group. From 4 day after treatment, number of Y maze active responses of rats enduring surgery under anesthesia was significantly less than those of rats in control group. At 1 and 7 day after treatment, serum level of IL-6 was significantly increased in rats of surgery under anesthesia group. Conclusion In our study, we successfully established anaged rat model of unilateral nephrectomy under isoflurane anesthesia. In those rats, the declined learn-ing and memory abilityand increased serum level of IL-6 werefound after treatment. These results suggested the increased serum level of IL-6 caused by surgical and anesthesia stress might contribute to learning and memory ability dysfunction.关键词
异氟烷/肾切除术/学习记忆/IL-6/大鼠Key words
isoflurane/unilateral nephrectomy/learning and memory/interleukin-6/rat分类
医药卫生引用本文复制引用
陈丽,龚春雨,张慧伟,王晓,李茁,王怀明,杨静..异氟烷麻醉下肾切除术对老年大鼠学习记忆能力的影响[J].四川医学,2015,(9):1205-1208,4.基金项目
国家自然科学基金(编号:81271201) （编号:81271201）
