山东医药Issue(35)：5-7,3.DOI:10.3969/j.issn.1002-266X.2015.35.002
乙型肝炎患者外周血中性粒细胞与淋巴细胞比值、红细胞分布宽度变化及意义
Clinical usefulness of measuring neutrophil-lymphocyte ratio and red blood cell distribution width in peripheral blood of patients with hepatitis B
摘要
Abstract
Objective To observe the changes of neutrophil-lymphocyte ratio ( NLR) and red blood cell distribution width (RDW) in the peripheral blood of hepatitis B virus (HBV)-infected patients and to investigate the significance. Methods Fouty-tow patients with chronic hepatitis B (CHB, group A), 40 patients with chronic severe hepatitis B ( CSHB, group B) and 45 normal healthy persons ( control group, group C) were enrolled in this study.According to me-dian value of NLR, group B was divided into two groups:group B1 including 20 patients ( NLR≤3.51) and group B2 in-cluding 20 patients (NLR>3.51).In all subjects, a blood sample was collected at admission to examine RBC, Hb, RDW, NLR and prothrombin activity ( PTA) , which were determined using XE-5000 automated hematology analyzer and STAGO STA-R automatic coagulation analyzer.Results Compared with group C, RDW was increased, and RBC and Hb were decreased in the group A ( all P<0.05);compared with group C, RDW and NLR were increased, and RBC and Hb were decreased in the group B (all P<0.05);compared with group A, RDW and NLR were increased and PTA,RBC and Hb were decreased in the group B;and statistical difference was found (all P<0.05).Moreover, the NLR level was nega-tively correlated with PTA (r=-0.5571, P<0.5).Patients in group B2 tended to be older, and had higher NLR values as compared with those of group B1 (all P<0.05).Conclusion RDW and NLR values are increased in patients with hepatitis B and the combined detection of them helps to determine the severity and degree of liver damage.关键词
中性粒细胞/淋巴细胞/红细胞分布宽度/肝炎/乙型肝炎Key words
neutrophil/lymphocytes/red blood cell distribution width/hepatitis/hepatitis B分类
医药卫生引用本文复制引用
龚娇,代航,胡波..乙型肝炎患者外周血中性粒细胞与淋巴细胞比值、红细胞分布宽度变化及意义[J].山东医药,2015,(35):5-7,3.基金项目
教育部第44批留学回国人员科研启动基金［教外司留（2012）9401］。 （）
