世界中医药Issue(8)：1163-1168,6.DOI:10.3969/j.issn.1673-7202.2015.08.008
肿瘤坏死因子α介导动脉粥样硬化发生机制的研究进展
Research Progress of Pathogenesis of Atherosclerosis Induced by Tumor Necrosis Factorα
摘要
Abstract
Atherosclerosis,which is the main consequence of a complicated inflammatory process,has threatened human health seriously.Tumor necrosis factor alpha is a multifunctional cytokine which is regarded to mediate the inflammatory response by acti-vating various signaling pathways.A large number of studies showed that tumor necrosis factor alpha could not only induce the in-jure of vascular endothelial cells and vascular smooth muscle cells,but also induced the migration of monocytes and endothelial cell adhesion and foam cell formation.At the same time,the stability of the plaque may also be affected,tumor necrosis factor alpha crucially involved in the pathogenesis and progression of atherosclerosis.This article made a review on the studies researched on pathogenesis of atherosclerosis due to tumor necrosis factor alpha.关键词
肿瘤坏死因子 α/动脉粥样硬化/发生机制Key words
Atherosclerosis/Tumor necrosis factor alpha/Pathogenesis分类
医药卫生引用本文复制引用
周平,罗云,邢娜,卢珊,孙桂波,孙晓波..肿瘤坏死因子α介导动脉粥样硬化发生机制的研究进展[J].世界中医药,2015,(8):1163-1168,6.基金项目
国家科技重大专项课题，重大新药创制基金（编号2012ZX09501001-004）；哈尔滨商业大学研究生创新项目 （）
